NORTHERN CALIFORNIA BRANCH OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE 

Job Type: Temporary to possibly permanent

Starting Hourly Salary: $15.00 - $17.00

MINIMUM QUALIFICATIONS:

• High school diploma or General Education Degree (G.E.D.)
• Demonstrated ability to perform in a physically demanding role including standing, lifting up to 50 pounds, moving about, and ascend and descend and work from a platform ladder.
• Participation in Weekend and Holiday Schedule Rotation Required.

• One (1) year of related experience in and/or training in animal husbandry.
• Six (6) or more months' experience working in a regulated environment, where tasks are performed according to standard operating procedures, rules, or regulations, where efficiency and accuracy are critical, and keeping accurate and thorough records are required (such as food service, CNA, etc. under FDA, Health Dept. regulations, etc.).
• AALAS certification at the Assistant Technician or its equivalent.

Department Description
The Institute for Neurodegenerative Diseases (IND) at UCSF is pursuing a cutting-edge blend of basic science and clinical medicine to provide outstanding care to those suffering from neurodegenerative diseases. Founded in 1999, the IND is committed to creating therapeutics that will halt diseases such as Alzheimer’s, Parkinson’s, Creutzfeldt-Jakob disease and dementia resulting from traumatic brain injuries. The IND is poised to make serious contributions to this struggle at the frontier of neuroscience and medicine. The mission of the Institute for Neurodegenerative Diseases is to discover causes and develop cures for these illnesses with an innovative program of basic research and clinical medicine.

Required Qualifications

• Graduation from high school, completion of training equivalent to the Laboratory Animal Technologist certification of the American Association for Laboratory Animal Science (AALAS), and three years of related animal care experience with demonstrated supervisory ability or an equivalent combination of education and experience; and knowledge and abilities essential to the successful performance of the duties assigned to the position
• Able to effectively follow Standard Operating Procedures as it relates to Environmental Health and Safety procedures (i.e. proper use of Personal Protective Equipment)
• Able to effectively and efficiently work well with other team-members in a high-throughput, dynamic, and physically-demanding environment
• Able to be responsible for inspection, observation, and treatment of unusual or unexpected conditions that arise, requiring immediate action and notification to a supervisor

• Laboratory Animal Technician (LAT) certification
• Familiarity with biomedical research and animal models of disease

• Completion of training equivalent to the Laboratory Animal Technologist certification of the American Association for Laboratory Animal Science (AALAS), or equivalent, see above

Duties include:

• Schedule, monitor, and supervise Animal Care Assistants performing animal husbandry and sanitation duties to ensure program and facility compliance for multiple locations. Coordinate staffing needs with other supervisors and facility managers to maintain adequate coverage of animal husbandry per operational needs.
• Provide ongoing education to technicians on best husbandry practices (weaning, sexing, housing, health observations, and cage cleaning); analyze any observed or reported abnormalities in animal health or behavior and discuss with staff veterinarians when warranted; stay abreast of new technologies in the industry and make recommendations for adapting standard protocols to incorporate these advances.
• Coach and develop technicians, and evaluate, provide feedback and document their performance. Counsel employees within the guidelines of the bargaining unit service agreement, and work directly with the Human Resources Manager and Employee and Labor Relations in disciplinary proceedings.
• Orient and train technicians on workplace protocols and safety, including but not limited to: proper use of personal protective equipment (PPE) (requirements vary according to animal room); material safety data sheets (MSDS); awareness of unique research animal facility environmental hazards; development of new or modification of existing standard operating procedures (SOPs) to meet current or future needs; completion of accident and injury investigation documentation, and identification of the root cause and appropriate remedy in a timely manner.
• Partner with research personnel to provide information and best practices regarding the treatment of animals, disease control measures, and nutritional requirements; on a daily basis, provide orientation to policies and procedures, enforce/audit compliance to internal policies, and use judgment to determine level of recourse when policy violations occur.
• Develop and implement strategies for assigning space to investigators to ensure efficient and effective use of animal facility space; enable maximum utilization in terms of the number of animals and caging; use independent discretion to reorganize space requirements to resources.
• Maintain appropriate documentation of animal husbandry, i.e. room check sheets, morbidity/mortality reports, and other documentation as requested by regulatory agencies and other reports needed by the Assistant Facility Operations Manager; analyze data to identify changes or trends that impact the research program.
• Oversee performance management of assigned staff; contribute recommendations on hire and fire decisions.

• Knowledge of supervisory practices and principles, with an active role in employee management and development.
• Familiarity with animal husbandry standards and regulatory requirements.
• Knowledge of standard operating procedures for the various species of animals used in biomedical research; USDA health and welfare standards; special handling techniques for biohazard, radioactive, or infectious materials; and standards outlined in the National Institutes of Health Guide for Care and Use of Laboratory Animals.
• Strong written and verbal communication and interpersonal skills.
• Demonstrated ability to work in a culturally diverse environment.
• Fluency in both spoken and written English.
• Excellent organization skills.
• Proficiency with Microsoft Office applications

• Frequently use a computer, stand/walk on hard surfaces, operate cage washing equipment.
• Occasionally sit, twist/bend/stoop/squat, reach/work above shoulders, grasp forcefully, use a telephone, sort/file paperwork or parts, lift/carry/push/pull objects that weigh >40 pounds.
• Rarely kneel/crawl, climb (ladders, scaffolds, or other), grasp lightly/fine manipulation, writing by hand, scrub/sweep/mop/chop/mix, operate foot and/or hand controls.
• Ability to work in a dusty, dirty and odorous environment.
• Must be free of animal related allergies.

• Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
• Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
• Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.

• Schedule: Full-time
• Job Code: 4920
• Employee Status: Regular
• Grade: H
• Requisition ID: 87864

EDUCATION & EXPERIENCE (REQUIRED):

• High School Diploma or GED.
• One year of applicable animal care experience in research or animal laboratory environment tor a combination of equivalent education and work experience

• In addition to the qualifications described for the Animal Care Assistant I level the Animal Care Assistant IIs should have:
• Familiarity with NIH guidelines, Stanford animal care and use policies, and USDA regulations.
• Ability to safely operate hand-truck, forklift, and pallet jack machines, as well as non-commercial vans, trucks and light transit vehicles

• Often lift and carry materials weighing up to 40 lbs.
• Frequently handle materials up to 20 lb .Occasionally carry/pull up to 60 pounds, push over 60 pounds
• Walk/stand for long periods.
• Bend, squat, reach above shoulder level.
• Often use hands to finger, handle, or feel objects, tools, or controls.
• Required vision abilities including close, distance, color, peripheral and depth perception.
• Ability to talk and to hear

• May be required to work overtime, evenings and weekends, including Holidays, sometimes in inclement weather conditions.
• Work in direct contact with animals and all components of animal housing and animal research environment.
• May be exposed to dust, fumes or gases, chemicals or toxic substances.

• When conducting university business, must comply with the California Vehicle Code and Stanford University driving requirements.
• Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
• Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
• Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu and the appropriate collective bargaining agreement at https://cardinalatwork.stanford.edu/hr-processes-policiespolicies/labor-relations-collective-bargaining.

• Schedule: Full-time
• Job Code: 5844
• Employee Status: Regular
• Grade: A16
• Requisition ID: 87793

What you will do:

• Provide primary veterinary care and triage expertise for the Animal Care Program, Vivarium and Research Operations and Scientific Investigator groups, and to assure animal welfare is maintained at the highest standard
• Assure best-in-practice veterinary standards are implemented and sustainable within the animal care program
• Apply your deep clinical knowledge and technical proficiency of animal physiology/anatomy, recognition of normal/abnormal behavior, to assess and treat clinical problems and animal welfare issues associated with in vivo procedures
• Lead the implementation and oversight of a veterinary care management software module
• Co-author and review policies and guidelines to meet animal care and use program standards
• Identify technical gaps and recommend solutions for communication and documentation as it pertains Veterinary Care
• Participate in technical training and competency assessments for in vivo staff (e.g. animal handling, dose administration, blood and tissue collections, anesthesia/analgesia, euthanasia)
• Develop, foster and maintain collaborative and team relationships with internal groups/ departments, and other organizations associated with the program

Qualifications:

• Associates (A.S. / A.A.) or Bachelors degree (B.A. /B.S.)
• 2+ year experience in a clinical veterinary practice setting
• 2+ year experience in a laboratory animal research setting and an understanding of the drug development process
• AALAS certification or Registered Veterinary Technician License (RVT) or equivalent preferred
• An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above
• Experience working in an animal program adhering to accreditation and regulatory standards (i.e. USDA, OLAW, FDA, AAALAC etc.) is strongly preferred

What you will do:

• Coordinate and facilitate IACUC and Animal Welfare activities across involved teams in support of R&D programs, coordinate and lead IACUC meetings, review IACUC Protocols/Amendments, and help generate reports for regulatory submissions
• Lead the implementation and maintain oversight of an animal care and use software management system (database for tracking protocols, amendments, training & communications)
• In conjunction with IACUC Chair and Attending Veterinarian, generate and revise IACUC Policies
• Identify process gaps and recommend solutions for record management and documentation as it pertains to the Animal Care Program
• Ensure compliance and timely updates to vivarium standard operating procedures, policies and guidelines to meet animal care and use program standards; author and review as requested
• Utilize your knowledge and technical proficiency of animal physiology/anatomy, recognition of normal/abnormal behavior, to make animal welfare assessments
• Assure basic training and competency assessments are performed and documented for in vivo staff; develop a technical training program (animal handling, dose administration, blood and tissue collections, euthanasia) suitable for regulatory and accreditation compliance
• Develop, foster and maintain collaborative and team relationships with internal groups/departments, and other organizations associated with the program

Qualifications:

• Bachelor's degree (B.A. /B.S.) with considerable knowledge of relevant animal welfare guidelines as it pertains to laboratory species, and an understanding of the drug development process
• 5+ year experience working in a laboratory animal research environment in a hands-on technical role
• AALAS certification or Registered Veterinary Technician License (RVT) or equivalent preferred
• An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above
• Compliance experience working in an animal program adhering to regulatory and accreditation standards (i.e. USDA, OLAW, FDA, AAALAC etc.) strongly preferred

What you will do:

• Execute in vivo pharmacology studies with disease models and conduct in vivo drug efficacy studies to support early drug discovery projects
• Support the development of, and adhere to study designs, SOPs and IACUC protocols
• Contribute to technical reports, publications, and participate in scientific conferences as applicable
• Perform in vivo procedures in rodents, including multiple routes of dose administration (IP, PO, IV, SC), blood collection, dissection techniques, and necropsies
• Organize, execute and maintain multiple experiments running in parallel
• Develop and troubleshoot novel in vivo disease models for mechanism of action studies
• Plan, execute, analyze, and document experiments
• Communicate study results to multiple stakeholders within the organization
• Work in a team environment and, as needed, trains new personnel
• Stay up to date with associated technology advancements

Qualifications:

• Bachelor's or Master's degree in a life science discipline
• 5+ years of hands-on laboratory experience conducting in vivo studies in rodents in the biotechnology/pharmaceutical industry is required
• Hands-on experience performing in vivo rodent procedures, preferably, using multiple dose routes (IV, PO, SC, IM), tissue sample collection, and evaluating PD endpoints
• Experience working in a GLP regulatory environment is a plus
• Background in pharmacology, toxicology or related disciplines is required. Direct experience with rodent liver fibrosis/cirrhosis models, hemodynamic monitoring a plus
• Experience with cell therapy, gene therapy, or rodent surgical technique is a plus
• AALAS certification at the LAT level or higher is preferred
• Ability to work independently and as part of a team required
• Organized, self-motivated, able to multitask and deliver results with a high degree of attention to detail to drive projects forward in a timely manner
• Excellent cross-functional interpersonal, verbal and written communication skills is essential in this small, collaborative work environment

Qualifications:

In hiring new employees, we look for people who are also inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of the company culture. Because we know that employees are critical to our success in bringing novel medicines to patients, we are dedicated to remaining a great place to work and to providing employees with programs, services and benefits that allow them to bring their best to the business and to their personal lives. We are looking for a team player who is a creative, independent thinker, thrives in a widely interdisciplinary environment, and enjoys working closely and communicating effectively with colleagues in extremely diverse fields.

The ideal candidate will be ACLAM board certified, board eligible, or have advanced experience and expertise in the area of lab animal medicine. The candidate must have the ability to obtain a veterinary medical license in California.

The ideal candidate will have experience in building and leading teams, managing people and animal research facilities, and have strong interpersonal and communication skills.

The ideal candidate will have experience providing excellent clinical and surgical care in the lab animal field, including transgenic rodents, providing technical support to research projects, collaborating with researchers, ensuring compliance with federal regulations and AAALACi standards, and training/teaching research and lab animal staff.

This position is located in SSF, but willingness to collaborate across time zones and occasional travel to the Dixon facility is a must.


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

Division: Discovery
Department: Biology
Reports To: Senior Scientist, Pharmacology
FLSA Status: Exempt
Effective Date: December 2019

EDUCATION/EXPERIENCE/SKILLS:
Education:

• BS in a relevant biological scientific discipline and two to four years of related experience; or,
• MS in a relevant biological scientific discipline and zero to two years of related experience
• Equivalent combination of education and experience

• Proficiency with in vivo techniques including iv, ip, sc, po administration, and blood collection (tail vein, retroorbital, cardiac puncture, submandibular and etc.) is required
• Proficiency in animal tumor model development and execution including but not limited to syngeneic, xenograft and humanized mouse model is essential
• Good practice with in vitro sterile cell culture and scale-up for tumor implantation is required
• Ability to conduct organ harvesting; transcardial perfusion and fixation from small animals
• Adept at sample processing, homogenization, or generation of single-cell suspensions for ex vivo analysis
• Experience with immunology-related biological assays, flow cytometry, MSD and Luminex is a plus
• Excellent data analysis skills and experience with a variety of scientific software applications is preferred
• Proficiency with computers including MS Word, MS PowerPoint, and MS Excel is required

• General knowledge of pharmacokinetics, pharmacology and immunology techniques, theories, and practices
• General understanding of how the individual experiments fit within a larger research program to meet organizational goals
• General understanding and application of scientific principles, theories and concepts in field of specialty and other related disciplines
• Ability to perform in a fast-paced environment and be flexible
• Ability to adapt to changing work conditions
• Must be self-motivated, able to multi-task and detail-oriented
• Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in a either a team environment or independently
• Understanding of regulatory requirements to run an in vivo facility
• Collaborate with other project team members

• Work on problems of diverse scope where analysis of data requires evaluation of identifiable factors
• Exercise judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions
• Use professional concepts and company policies and procedures to solve a wide range of difficult problems in imaginative and practical ways

Division: Discovery
Department: 10231 Discovery Biology
Reports To: Scientist I
FLSA Status: Exempt
Effective Date: June 2020

SUPERVISORY RESPONSIBILITIES:
None

EDUCATION/EXPERIENCE/SKILLS:
Education:

• Bachelor’s degree (B.A./B.S.) in related discipline and up to two years of relevant experience; or
• Equivalent combination of education and experience.

• Proficient with in vivo techniques including animal handling, dosing methods (iv, ip, sc, po), blood collection techniques (tail vein, RO, cardiac puncture, etc.), tumor implantation and measurement, and tissue collection from small laboratory animals.
• Experience with aseptic technique, in vitro cell culture and cell culture scale-up for implantations is preferred.
• Experience handling and processing biological samples in a laboratory setting.
• Excellent data analysis skills and experience with a variety of scientific software applications is preferred.
• Proficiency with computers including MS Word, MS PowerPoint, and MS Excel is required. Experience with GraphPad Prism and StudyLog software is preferred.

• General knowledge of pharmacokinetics, pharmacology and vivarium techniques, theories, and practices.
• General understanding of how individual experiments fit within a larger research program to meet organizational goals.
• General understanding and application of scientific principles, theories and concepts in field of specialty and other related disciplines.
• Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in a either a team environment or independently.
• Collaborate with other project team members.

• Work on problems of diverse scope where analysis of data requires evaluation of identifiable factors.
• Exercise judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions.

Our lab:
The Tsao lab (http://tsaolab.caltech.edu/) studies the neural mechanisms underlying vision in non-human primates and mice. We study questions related to object recognition, spatial perception, memory, and consciousness. We use multiple approaches including functional MRI (fMRI), electrophysiology, widefield and two-photon imaging, and mathematical modeling.

Work with Non-Human Primates:
The job will involve hands-on coordination of our animal colony (overseeing the health and welfare of the animals, interfacing with animal care and veterinary staff), assisting with surgeries and anesthesia, preparing and administering medications, and training animals on behavioral tasks.

Research and Management:
The Lab Manager will assist with fMRI experiments and other ongoing projects in the lab. Responsibilities also include purchasing and maintenance of equipment and supplies and maintenance of laboratory records. The Lab Manager also coordinates projects with other offices and labs on campus to ensure compliance and safety.


For more information or to apply, please email Doris Tsao (dortsao@caltech.edu). Please include a CV and contacts of at least two references in your application.

Benefits of being an Apex Employee:

• One Paid AALAS Certification (ALAT, LAT, LATG)
• PTO, Sick Time and Holiday pay
• Attendance and performance incentives and team building activities
• Medical, Vision and Dental coverage options
• Long and Short Term Disability, Life Insurance, Employee Stock Purchase Plan, 401(k) plan, Transit Account and additional Insurance offerings